Welcome to MIROCALS

Making Strides in Understanding Amyotrophic Lateral Sclerosis

Welcome to the official homepage of MIROCALS (Modifying Immune Response and Outcomes in Amyotrophic Lateral Sclerosis), a pioneering clinical research study that aims to advance our understanding and treatment of Amyotrophic Lateral Sclerosis (ALS). This progressive and debilitating disease affects nerve cells in the brain and spinal cord, causing muscle weakness and atrophy, leading eventually to paralysis and respiratory failure. Our mission is to explore new avenues for slowing down disease progression, improving patient outcomes, and offering hope for a brighter future.


With the unfortunate reality that there is currently no cure for ALS, there is an urgent need for innovative approaches to treatment. MIROCALS stands at the forefront of this endeavor, focusing on the role of immune modulation as a novel strategy for disease management. Our research explores the safety and efficacy of low-dose Interleukin-2 (IL-2), an immune system regulator. By modulating the immune system, we aim to manage the overactive immune responses believed to contribute to the degeneration of motor neurons in ALS patients.

The Science Behind MIROCALS

Interleukin-2 (IL-2) is a cytokine that plays a critical role in the immune system. While high doses of IL-2 have been used in cancer treatments, MIROCALS employs low-dose IL-2 with the aim of expanding regulatory T cells. These cells are pivotal in controlling autoimmune responses and inflammation. By modulating the balance of immune cells, we aspire to create a more hospitable environment for motor neurons, potentially slowing down the disease process.

Our Approach

MIROCALS is designed as a multi-center, randomized, placebo-controlled clinical trial. This robust study structure allows us to minimize biases and provides compelling data on the safety and efficacy of low-dose IL-2. Our work involves renowned research centers across Europe, combining expertise from various domains such as neurology, immunology, and data science to give us a comprehensive understanding of the potential of IL-2 in ALS treatment.

Who Can Participate?

Eligibility for participating in our trial is determined through a rigorous screening process. The criteria include a confirmed diagnosis of ALS, among other health metrics and considerations. Our focus is not just on the biological aspects of the disease but also on the overall well-being of participants. If you’re interested in participating, please consult our ‘Participation’ section for comprehensive eligibility details.

The Road Ahead

The fight against ALS is a marathon, not a sprint. While MIROCALS is a significant step forward, it is a part of a long-term initiative. Our work complements other research projects worldwide, contributing to a growing body of knowledge aimed at unravelling the mysteries of ALS and other neurodegenerative diseases. As we gather more data, our findings will be published in peer-reviewed scientific journals and presented at international conferences, thereby contributing to the global dialogue on ALS.

How to Support Us

While our primary focus is scientific research, we believe in the power of community. Your support, whether it’s by spreading awareness, participating in the trial, or financial contributions, can make a significant impact. Visit our ‘Support Us’ page to find out how you can help us make a difference in the lives of ALS patients and their families.

Contact Us

For more information, feel free to reach out to us via our ‘Contact’ page. Whether you’re a patient, a caregiver, a healthcare professional, or simply someone interested in ALS research, your inquiries are always welcome.

Thank you for visiting the MIROCALS homepage. Together, we can push the boundaries of what’s possible in ALS research and treatment.